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  • Title: TMC-66, a new endothelin converting enzyme inhibitor produced by Streptomyces sp. A5008.
    Author: Asai Y, Nonaka N, Suzuki S, Nishio M, Takahashi K, Shima H, Ohmori K, Ohnuki T, Komatsubara S.
    Journal: J Antibiot (Tokyo); 1999 Jul; 52(7):607-12. PubMed ID: 10513839.
    Abstract:
    A new endothelin converting enzyme (ECE) inhibitor, TMC-66 was isolated from the fermentation broth of Streptomyces sp. A5008. The structure of TMC-66 was elucidated by spectroscopic analyses to be a new member of benzo[a]naphthacenequinone class of antibiotics. TMC-66 had a highly selective inhibitory activity for ECE with an IC50 value of 2.9 microM. Taxonomy of the producing strain is also described.
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