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  • Title: Synthesis of some new pyridyl-ethylated benzoxazolinones with analgesic and anti-inflammatory activities.
    Author: Palaska E, Gökhan N, Erdoğan H, Tel BC, Demirdamar R.
    Journal: Arzneimittelforschung; 1999 Sep; 49(9):754-8. PubMed ID: 10514903.
    Abstract:
    Twelve new 3-[2-(2- and/or 4-pyridyl)ethyl]benzoxazolinone derivatives have been synthesized by reacting 2- and/or 4-vinylpyridine and appropriate benzoxazolinones. Their chemical structures have been proven by IR, 1H-NMR and elemental analysis. Analgesic activities of these compounds were investigated by a modified Koster and constant temperature hot-plate test. Test results revealed that most of the compounds at 100 mg/kg dose level showed significant analgesic activities when compared to acetylsalicylic acid and morphine. Therefore the compounds were screened for their anti-inflammatory activities using the carrageenan hind paw edema test. Compounds 3-8 were found more active than indometacin. In gastric ulceration studies, any of the compounds showed no gastrointestinal bleeding at 100 mg/kg dose level.
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