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  • Title: Hypocomplementemic urticarial vasculitis or systemic lupus erythematosus?
    Author: Trendelenburg M, Courvoisier S, Späth PJ, Moll S, Mihatsch M, Itin P, Schifferli JA.
    Journal: Am J Kidney Dis; 1999 Oct; 34(4):745-51. PubMed ID: 10516358.
    Abstract:
    The 2 patients presented here showed the typical signs of hypocomplementemic urticarial vasculitis syndrome (HUVS). During follow-up, there was an inverse correlation between anti-C1q autoantibody titer and C1q antigen concentration in serum in both patients over a period of 2 years. The first patient had nephritis characterized by immune deposits in glomeruli and around the tubules. The histological findings, C1q deposits, and presence of tubuloreticular inclusions in capillary endothelial cells suggested a disease process identical to systemic lupus erythematosus (SLE). The second patient, after a lag phase of 2 years, fulfilled a fourth American College of Rheumatology criteria for SLE when she developed anti-double-stranded DNA antibodies. HUVS and SLE overlap, and the criteria for identifying HUVS as an entity distinct from SLE are lacking.
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