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  • Title: Enhancement of CO2-induced anxiety in healthy volunteers with the serotonin antagonist metergoline.
    Author: Ben-Zion IZ, Meiri G, Greenberg BD, Murphy DL, Benjamin J.
    Journal: Am J Psychiatry; 1999 Oct; 156(10):1635-7. PubMed ID: 10518177.
    Abstract:
    OBJECTIVE: The mechanism of action of CO2-induced anxiety is unknown and has been little studied. The authors studied healthy volunteers for the possible influence of serotonin (5-HT) on CO2-induced anxiety. METHOD: Fourteen healthy volunteers received two vital capacity inhalations each of 35% CO2 and of air, preceded once by placebo and once by the 5-HT antagonist metergoline in a double-blind, randomized crossover design. RESULTS: Mean National Institute of Mental Health self-rating anxiety subscale scores increased nonsignificantly after CO2 inhalation; this effect was significantly enhanced by the administration of metergoline. CONCLUSIONS: The authors hypothesize that 5-HT may inhibit CO2-induced anxiety, a function that is lessened by metergoline.
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