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  • Title: Hb-Alberta or alpha2beta2 (101(G3) Glu replaced by Gly), a new high-oxygen-affinity hemoglobin variant causing erythrocytosis.
    Author: Mant MJ, Salkie ML, Cope N, Appling F, Bolch K, Jayalakshmi M, Gravely M, Wilson JB, Huisman TH.
    Journal: Hemoglobin; ; 1(2):183-94. PubMed ID: 1052180.
    Abstract:
    Hb-Alberta has been found in a 51 year old Caucasian male with erythrocytosis. The substitution in this variant involves the glutamyl residue in position 101(G3) of the beta chain which is replaced by a glycyl residue. Hb-Alberta accounts for about 45% in the heterozygote, and readily forms hybrid tetramers with other hemoglobins. The oxygen affinity of Hb-Alberta is greatly increased, its Bohr effect reduced, and its subunit interaction greatly diminished.
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