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  • Title: Generalized eruptive histiocytoma of childhood associated with rheumatic fever.
    Author: Matsushima Y, Ohnishi K, Ishikawa O.
    Journal: Eur J Dermatol; 1999; 9(7):548-50. PubMed ID: 10523734.
    Abstract:
    We describe a widespread papular eruption in a 5-year-old girl with rheumatic fever. Histological examination revealed a dense histiocytic infiltration in the dermis. On immunohistochemical studies, the cells were positive for vimentin, CD68, MAC387, alpha1-antichymotrypsin and lysozyme, but negative for CD1a and S-100 protein. Electron microscopic studies showed no Birbeck granules in their cytoplasm. A diagnosis of generalized eruptive histiocytoma of childhood was established. The skin lesions completely disappeared within 8 months.
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