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  • Title: Investigation of the alveolar macrophages and T lymphocytes in 15 patients with systemic sclerosis.
    Author: Czirják L, Koncz A, Varga I, Dévényi K, Kumánovics G, Szücs G.
    Journal: Clin Rheumatol; 1999; 18(5):357-63. PubMed ID: 10524548.
    Abstract:
    The cell distribution and function of alveolar macrophages and T lymphocytes were investigated in the bronchoalveolar lavage (BAL) of 15 patients with systemic sclerosis (SSc). In alveolar macrophages, both spontaneous and PMA-stimulated TNF-alpha production were increased in SSc. PMA-induced IL-6 production was also elevated. Spontaneous IL-6 excretion of scleroderma alveolar macrophages was similar to the controls. Yeast and C3b-coated yeast (opsonised yeast) phagocytosis, chemotaxis and Fc receptor activity of alveolar macrophages were normal. The proportion of CD3, CD4 and CD8 T-lymphocyte subsets in the BAL was similar to the control values. The lymphocyte blast transformation index of the non-adherent cells deriving from the BAL fluid was markedly decreased.
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