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  • Title: Neuropathology of parkinsonism-dementia complex and amyotrophic lateral sclerosis of Guam: an update.
    Author: Oyanagi K, Wada M.
    Journal: J Neurol; 1999 Sep; 246 Suppl 2():II19-27. PubMed ID: 10525999.
    Abstract:
    A comparative study was performed to investigate the differences and similarities of the neuropathological findings in the parkinsonism-dementia complex (PDC) and amyotrophic lateral sclerosis (ALS) of Guam, progressive supranuclear palsy and classic ALS. Based on the findings, it is proposed that (a) PDC is a discrete disease entity, (b) NFTs in Chamorro ALS are merely a background feature widely distributed in this population, (c) Chamorro ALS is a disease combined with classic ALS and neurofibrillary degeneration, (d) thus a subtype of "Guam ALS" is not present, and (e) PDC and ALS of Guam are different diseases.
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