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  • Title: [Hypophyseal-hypothalamo-thyroid axis in affective disorders].
    Author: Hofmann P, Schrötter KH.
    Journal: Acta Med Austriaca; 1999; 26(4):123-5. PubMed ID: 10526629.
    Abstract:
    For centuries there has been convincing evidence that diseases of the thyroid gland may produce psychiatric symptoms. Nowadays systematic data are available concerning a higher incidence of thyroid diseases in psychiatric patients and vice versa a higher incidence of psychiatric disorders in thyroid patients. A more subtle approach concerns challenge tests like the TRH test. It could be shown that depressive patients show a blunted TSH response to TRH in 30-40% of the cases. This might lead to a definition of a subgroup of depressives from a psychoneuroendocrinological point of view. But it also might have an impact on the prediction of treatment outcome in psychopharmacological treatment approaches.
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