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  • Title: [The familial incidence of accessory atrioventricular pathways (the pre-excitation syndrome)].
    Author: Gutiérrez Rojas A, Iturralde Torres P, Colín Lizalde L, Victoria D, González Hermosillo JA, Cárdenas Loaeza M.
    Journal: Arch Inst Cardiol Mex; 1999; 69(3):228-34. PubMed ID: 10529856.
    Abstract:
    Cases of familial preexcitation syndrome represent a specific subgroup of patients that may result from diverse mechanisms: failure in development and genetic predisposition are the main mechanism involved. We determined the prevalence of this syndrome in first degree relatives of patients with proved accessory pathways by electrophysiologic study and compared such prevalence with the general population (0.15%). In five out of 469 patients (1.06%) we found an accessory pathway in one or more member of their family. Only 6 out of 3752 had preexcitation (0.15%); this prevalence was similar to the general population (P = NS). The identification of family members with this syndrome may be incomplete because we only chose for the study symptomatic patients. We did not observed multiple pathways and in one case we found atrial septal defect. Our data demonstrated familial preexcitation in five families suggesting hereditary predisposition.
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