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  • Title: Structural and functional analysis of ribosome subunits isolated from mouse liver following a toxic dose of dimethylnitrosamine.
    Author: Delpino A, Ferrini U.
    Journal: Arch Sci Biol (Bologna); 1976; 60(1-4):49-58. PubMed ID: 1053014.
    Abstract:
    Ribosomal subunits, isolated from mouse liver after a single dose of 50 mg/Kg b. w. of DMN, have been tested for their structural and functional properties. CsCl analysis has shown that after DMN treatment no loss of structural proteins occurs in both 40 S and 60 S ribosome subunits. It has been also demonstrated that these subunits are able to synthetize in the poly-U programmed system at low Mg++ concentrations, in the presence of heterologous initiation factors, at the same efficiency as the corresponding controls.
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