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  • Title: Design and synthesis of a novel series of HIV-1 protease inhibitors.
    Author: Takashiro E, Nakamura Y, Miyamoto S, Ozawa Y, Sugiyama A, Fujimoto K.
    Journal: Bioorg Med Chem; 1999 Sep; 7(9):2105-14. PubMed ID: 10530961.
    Abstract:
    The synthesis and the SAR study of novel pseudo symmetric inhibitors of HIV-1 protease are described. Michael addition of amino acid derivatives to vinyl ketones was utilized to derive a potent (nM) series of HIV-1 protease inhibitors.
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