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  • Title: [Dose-response relationship of repeated injections of pentagastrin on the vagally innervated rat stomach in perfusion experiments].
    Author: de Boer A, Hantschmann N.
    Journal: Z Exp Chir; 1975; 8(6):343-9. PubMed ID: 1053193.
    Abstract:
    In the perfusion model under urethane anesthesia Wistar rats were two times injected pentagastrin subcutaneously in a distance of 150 minutes in dose rates of 50, 100, 150, 200, 250 and 300 microgram/kg b. w. The results may be summarized as follows: 1. The dose of 200 microgram/kg b. w. of pentagastrin produced the maximal answer. Higher doses showed a diminished acid secretion. 2. The diminished effect of higher doses of gastrin may be caused by a hypothetical inhibitor which may be more effective after truncal vagotomy. 3. The repeated injection of pentagastrin did not show a significant difference of the answer. The second injection was given after the acid secretion has returned to the basal level. No tachyphylaxy was seen under these conditions.
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