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  • Title: Reciprocal adaptive response of human peripheral lymphocytes induced by bleomycine or gamma rays.
    Author: Kalina I, Brezáni P, Habalová V, Kohút A, Biros E, Némethová G, Salagovic J.
    Journal: Physiol Res; 1999; 48(2):171-4. PubMed ID: 10534022.
    Abstract:
    The adaptive response and reciprocal adaptive response induced in vitro by exposure to low doses of gamma rays (0.05 Gy) or bleomycin (0.05 microg/ml) in human peripheral blood lymphocytes were assessed by the frequency of chromosome aberrations. Gamma rays (1.5 Gy) or bleomycin (1.5 microg/ml) were used as the challenge doses. In the experiments, blood samples from 5 healthy donors were investigated. It has been found that low doses of bleomycin and gamma rays induced a reciprocal adaptive response to high doses of gamma rays or bleomycin. Moreover, the results confirmed that the adaptive response did not correlate with the radiosensitivity of the peripheral blood lymphocytes.
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