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Title: Enhanced theophylline metabolism in patients with bronchial asthma at age 4 and under. Author: Kizu J, Arakawa M, Arakawa Y, Komoda F, Takamizawa M, Iwata T, Hayakawa T, Imai K. Journal: Biomed Chromatogr; 1999 Nov; 13(7):462-4. PubMed ID: 10534757. Abstract: The plasma levels of theophylline (TP) and its metabolites were measured in patients with bronchial asthma who were treated with a slow-release preparation of TP. The ratios of the plasma levels of these metabolites to TP levels in the group aged 1-4 years were larger than those in the group aged 5 years and older, suggesting enhanced activity of drug-metabolizing enzymes during infancy.[Abstract] [Full Text] [Related] [New Search]