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  • Title: Oral glycopyrrolate alleviates drooling in a patient with tongue cancer.
    Author: Olsen AK, Sjøgren P.
    Journal: J Pain Symptom Manage; 1999 Oct; 18(4):300-2. PubMed ID: 10534970.
    Abstract:
    Although sialorrhea and drooling are uncommon symptoms in cancer patients, they can cause considerable discomfort, inconvenience and social embarrassment. In this article we describe a patient with tongue cancer who was successfully treated with oral glycopyrrolate 0.4 mg 3 times daily. Glycopyrrolate is a quaternary ammonium compound. In contrast to the recommended treatment with scopolamine, glycopyrrolate is virtually without side effects to the central nervous system because it penetrates the blood-brain barrier poorly. Glycopyrrolate has a slow and erratic absorption from the gastrointestinal system, but even low plasma levels are associated with a distinct and long-lasting antisialogic effect.
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