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  • Title: Acute lymphoblastic leukemia terminating as histiocytic medullary reticulosis.
    Author: Shreiner DP.
    Journal: JAMA; 1975 Feb 24; 231(8):838-40. PubMed ID: 1053804.
    Abstract:
    A young man with acute lymphoblastic leukemia was treated with vincristine sulfate, prednisone, and intrathecally injected methotrexate sodium for central nervous system involvement. A good remission was induced, but three months later he had hepatosplenomegaly, an enlarging mediastinal mass, and progressive anemia. Histiocytic medullary reticulosis was confirmed by a bone marrow biopsy specimen. The patient died of respiratory failure because of infiltration of the lungs by malignant histiocytes.
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