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  • Title: Target-controlled remifentanil in combination with propofol for spontaneously breathing day-case patients.
    Author: Murdoch JA, Hyde RA, Kenny GN.
    Journal: Anaesthesia; 1999 Nov; 54(11):1028-31. PubMed ID: 10540089.
    Abstract:
    Remifentanil is a new potent opioid with a very short duration of action irrespective of duration of infusion. It may have a role in day-case anaesthesia as part of a balanced total intravenous anaesthetic technique with propofol. We examined the respiratory depressant effects of remifentanil in 20 patients undergoing day-case anaesthesia. The target plasma concentration of remifentanil was varied while maintaining a constant target-controlled infusion of 4.5 microg x ml-1 propofol. In only 12 patients was satisfactory spontaneous respiration maintained. In these patients the median remifentanil target concentration was 1.6 ng x ml-1 and was achieved with a median infusion rate of 0.05 microg x kg-1 x min-1. The range of target concentrations associated with satisfactory spontaneous respiration was wide and varied over a 4.7-fold range from 0.6 to 2.8 ng x ml-1.
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