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  • Title: [Molecular mechanism of vitamin E transport in the body].
    Author: Arai H.
    Journal: Nihon Rinsho; 1999 Oct; 57(10):2276-83. PubMed ID: 10540874.
    Abstract:
    Vitamin E occurs in nature in eight different forms, but animal body is enriched in alpha-tocopherol compared with other forms. alpha-Tocopherol transfer protein (alpha-TTP) is a liver cytosolic protein, which specifically binds alpha-tocopherol, and plays an important role in the discrimination of various tocopherols in the body. Furthermore, alpha-TTP is a product of the causative gene for familial isolated vitamin E deficiency. Using cell culture system, it was shown that alpha-TTP functions to enhance secretion of alpha-tocopherol from liver cells and that the reaction utilizes a novel non-Golgi mediated pathway which may be linked to cellular cholesterol metabolism and/or transport.
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