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  • Title: Folding alphabets.
    Author: Chan HS.
    Journal: Nat Struct Biol; 1999 Nov; 6(11):994-6. PubMed ID: 10542084.
    Abstract:
    A new computational approach optimizes searches for reduced protein folding alphabets that use fewer than 20 types of amino acids. The predicted optimal five-letter alphabet happens to be in agreement with the suggestive results of a recent experiment, but whether highly reduced alphabets are sufficient for truly protein-like properties remains an open experimental question.
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