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  • Title: [Pharmacokinetic study of 14C-carbaryl in pregnant mice (author's transl)].
    Author: Declume C, Benard P.
    Journal: Toxicol Eur Res; 1978 May; 1(3):173-80. PubMed ID: 105427.
    Abstract:
    The distribution of a single oral dose of 1-naphthyl-N-méthyl 14C-carbamate (Carbaryl), a cholinesterase inhibitor, in pregnant mice (18th day) was determined by whole-body autoradiography and 14C-activity counting of main organs. Although most of the 14C was quickly eliminated (24 h), mainly by the biliary route, there was retention in the maternal organs. Placental transfer of the radioactivity was rapid and readily detectable 5 h after administration. Radioactivity in the foetus remained higher than in the maternal kidney, spleen and heart and persisted after birth. Localisation in foetal eye, liver and central nervous system was observed.
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