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  • Title: Long-term second remissions in acute lymphatic leukemia.
    Author: Leventhal BG, Levine AS, Graw RG, Simon R, Freireich EJ, Henderson ES.
    Journal: Cancer; 1975 Apr; 35(4):1136-40. PubMed ID: 1054285.
    Abstract:
    Long-term second remissions were seen in 5/66 patients with all. Relapse was extramedullary in 2/5. Persistent, progressive marrow lymphocytosis preceded relapse in 4/5 patients and persistent marrow eosinophilia in 1/5. All 5 patients had had an unmaintained remission of at least 6 months prior to relapse, and responded the second time to drugs which were essentially the same as those used initially. We conclude that long-term second remissions may occur in all. Patients who relapse after 6 months or more of unmaintained remission should be treated with the drugs used in current initial induction regimens in hope of cure.
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