These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Idiopathic myelofibrosis with extramedullary hematopoiesis in the kidneys.
    Author: Schnuelle P, Waldherr R, Lehmann KJ, Woenckhaus J, Back W, Niemir Z, van der Woude FJ.
    Journal: Clin Nephrol; 1999 Oct; 52(4):256-62. PubMed ID: 10543329.
    Abstract:
    Extramedullary hematopoiesis is a common finding in idiopathic myelofibrosis and is usually found in liver and spleen. We report on a patient with biopsy-proven myeloid metaplasia and fibrosis of the renal parenchyma as a rare cause of chronic renal failure. The renal biopsy specimen showed numerous infiltrates of hematopoietic cells expressing growth factors like M-CSF, GM-CSF, IL-1beta and PDGF while TGF-beta was not elevated. These findings suggest that hematopoietic growth factors play a key role in the pathogenesis of this condition causing proliferating fibrosis and enlargement of the kidneys.
    [Abstract] [Full Text] [Related] [New Search]