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  • Title: X-ray crystallographic visualization of drug-nucleic acid intercalative binding: structure of an ethidium-dinucleoside monophosphate crystalline complex, Ethidium: 5-iodouridylyl (3'-5') adenosine.
    Author: Tsai CC, Jain SC, Sobell HM.
    Journal: Proc Natl Acad Sci U S A; 1975 Feb; 72(2):628-32. PubMed ID: 1054844.
    Abstract:
    We have cocrystallized the drug ethidium bromide with the dinucleoside monophosphate 5-iodouridylyl(3'-5')adenosine and have solved the three-dimensional structure to atomic resolution by x-ray crystallography. This has allowed the direct visualization of intercalative binding by this drug to a fragment of a nucleic acid double helix.
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