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  • Title: Clonal acquisition of the Ly49A NK cell receptor is dependent on the trans-acting factor TCF-1.
    Author: Held W, Kunz B, Lowin-Kropf B, van de Wetering M, Clevers H.
    Journal: Immunity; 1999 Oct; 11(4):433-42. PubMed ID: 10549625.
    Abstract:
    Families of clonally expressed major histocompatibility complex (MHC) class I-specific receptors provide specificity to and regulate the function of natural killer (NK) cells. One of these receptors, mouse Ly49A, is expressed by 20% of NK cells and inhibits the killing of H-2D(d) but not D(b)-expressing target cells. Here, we show that the trans-acting factor TCF-1 binds to two sites in the Ly49A promoter and regulates its activity. Moreover, we find that TCF-1 determines the size of the Ly49A NK cell subset in vivo in a dosage-dependent manner. We propose that clonal Ly49A acquisition during NK cell development is regulated by TCF-1.
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