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  • Title: Antineutrophil cytoplasmic antibodies in systemic lupus erythematosus in childhood.
    Author: Faure-Fontenla MA, Rodríguez-Suárez RS, Arias-Velásquez R, García-González JE.
    Journal: J Rheumatol; 1999 Nov; 26(11):2480-1. PubMed ID: 10555913.
    Abstract:
    OBJECTIVE: Antineutrophil cytoplasmic antibodies (ANCA) have been found in up to 25% of adults with systemic lupus erythematosus (SLE) and in 69% of affected children. We investigated ANCA and antibodies to myeloperoxidase (MPO) in 50 children with SLE. METHODS: ANCA in serum were measured by indirect immunofluorescence and antibodies to MPO by ELISA. RESULTS: ANCA were found in 8 (7 perinuclear ANCA, 1 cytoplasmic ANCA) of the 50 sera tested (16%). All the 8 ANCA positive patients were also positive for anti-MPO antibodies. No association with vasculitis or specific organ involvement was observed. CONCLUSION: Our results in children are roughly similar to those reported for adults.
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