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  • Title: Exploration of the association between apoptosis and cleft palate.
    Author: Chen Y, Huang H.
    Journal: Chin J Dent Res; 1999 Feb; 2(1):50-3. PubMed ID: 10557184.
    Abstract:
    OBJECTIVE: To explore the significance and effect of apoptosis in the development of cleft palate induced by dexamethasone (DEX). METHODS: Various doses of DEX (10-50 mg/kg) were injected intraperitoneally into Kunming mice on gestation day (GD) 12. The cranio-maxillary sections of samples were labeled by HRP-avidin-biotin-dUTP in situ end-labeling (ISEL) and were observed morphologically and quantitatively under a light microscope and electron microscope. RESULTS: ISEL positive cells were found in treatment groups. The means of sums and cleft palate incidence have a positive correlation with the doses of DEX (r = 0.9911/0.9978). CONCLUSION: A relationship exists between an increased level of apoptosis and the development of cleft palate induced by DEX.
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