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  • Title: Osteoarthrosis of the temporomandibular joint induced by intra-articular injection of lactate dehydrogenase: an experimental study in adult rabbits.
    Author: Tian H, Zhang ZG, He YQ, Chen XR.
    Journal: Chin J Dent Res; 1998 Sep; 1(2):62-7. PubMed ID: 10557197.
    Abstract:
    OBJECTIVE: The purpose of this study was to establish an animal model of osteoarthrosis in the temporomandibular joint (TMJOA) by injecting lactate dehydrogenase (LDH) into the maxillary compartments of TMJs in adult rabbits. METHODS: Adult New Zealand white rabbits were randomly divided into four groups (A through D) of five animals each. The A and B groups were used as a control. The maxillary compartments of the C and D group (TMJs) were injected with 0.1 mL of LDH in two different concentrations. The TMJ samples were analyzed histologically and with a scanning electron microscope four different times after injection. RESULTS: The animals that had been injected with LDH at two different concentrations showed similar results. The TMJs had changes typical of OA in early to moderate stages. No pathologic changes could be found in the TMJs of the control groups. CONCLUSIONS: The results suggest that LDH may be of use in establishing an animal model of TMJOA.
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