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  • Title: Centrosome duplication in mammalian somatic cells requires E2F and Cdk2-cyclin A.
    Author: Meraldi P, Lukas J, Fry AM, Bartek J, Nigg EA.
    Journal: Nat Cell Biol; 1999 Jun; 1(2):88-93. PubMed ID: 10559879.
    Abstract:
    Centrosome duplication is a key requirement for bipolar spindle formation and correct segregation of chromosomes during cell division. In a manner highly reminiscent of DNA replication, the centrosome must be duplicated once, and only once, in each cell cycle. How centrosome duplication is regulated and coordinated with other cell-cycle functions remains poorly understood. Here, we have established a centrosome duplication assay using mammalian somatic cells. We show that centrosome duplication requires the activation of E2F transcription factors and Cdk2-cyclin A activity.
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