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  • Title: [A case report: successful resection of advanced intrahepatic cholangiocarcinoma responding to preoperative hepatic artery infusion of 5-FU].
    Author: Hasuike Y, Motoori M, Hattori T, Fujita J, Mishima H, Sawamura T, Nishishou I, Kikkawa N, Sai H, Hosoki T, Mitomo M.
    Journal: Gan To Kagaku Ryoho; 1999 Oct; 26(12):1909-12. PubMed ID: 10560423.
    Abstract:
    A patient with advanced intrahepatic cholangiocarcinoma had a tumor embolus in the right main branch of the portal vein and lymph node metastases. Hepatic arterial infusion (HAI) therapy with 5-FU (1 g/day) was given as a continuous infusion for 6 days. The treatment was repeated after a one-week interval. As a result the tumor diameter decreased by half, and the tumor embolus contracted. Cytoreductive surgery was then performed. The patient has been disease-free for over 9 months postoperatively with adjuvant HAI with 5-FU. We consider preoperative HAI with 5-FU (two courses of 1 g/day x 6 days) is both safe and effective.
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