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  • Title: [P53-status of cells from patients with progeria and ataxia-telangiectasia exposed to ionizing irradiation].
    Author: Smirnova NV, Spivak IM, Mikhel'son VM.
    Journal: Tsitologiia; 1999; 41(8):721-8. PubMed ID: 10563391.
    Abstract:
    P53 protein expression and stabilization in cell strains derived from patients suffering from progeria and ataxia-telangiectasia following gamma-irradiation have been described. A similar pattern of P53-status in healthy donor and progeria patient cells was shown using immunofluorescent cell staining. In ataxia-telangiectasia cells (strain AT2SP) the P53 protein was not detected by the same method. These data well compare with literary evidence on a disturbed P53-status at ataxia-telangiectasia.
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