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  • Title: Psychological and sympatho-adrenal status in patients with cystic acne.
    Author: Schulpis K, Georgala S, Papakonstantinou ED, Michas T.
    Journal: J Eur Acad Dermatol Venereol; 1999 Jul; 13(1):24-7. PubMed ID: 10565626.
    Abstract:
    BACKGROUND: Patients with cystic acne (CA) frequently report feeling self conscious, anxiety and social isolation. METHODS: Mood characteristics as well as self-esteem scores of 38 patients with CA were evaluated before and after 30 days treatment with isotretinoin. A high pressure, liquid chromatography method was used for the evaluation of catecholamines (epinephrine (E) and nor-epinephrine (NE)) in the blood of the patients at the time of the study and in controls (n = 30) after their psychological testing. Moreover, E and NE were measured in the blood of eight healthy volunteers before and after 1 month 'treatment' with the drug. RESULTS: The CA subjects evidenced anxiety and high catecholamine plasma levels (E = 98.0+/-0.8 pg/ml, NE = 250.8+/-56.6 pg/ml) before treatment compared to controls (E = 71.8+/-23.0 pg/ml, NE = 190.0+/-52 pg/ml, P < 0.006), and these levels were lower (E = 75.4+/-21.4 pg/ml, NE = 202.0+/-49.9 pg/ml, P < 0.001) when their psychological status returned to normal after treatment. No differences were observed in E and NE levels in the eight healthy volunteers who received the same dose of the drug at the same time of study. CONCLUSIONS: It is suggested that not only the psychological status is influenced in subjects with CA but also their sympathoadrenal system.
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