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  • Title: Biochemical studies on a novel antioxidant from lemon oil and its biotechnological application in cosmetic dermatology.
    Author: Calabrese V, Randazzo SD, Catalano C, Rizza V.
    Journal: Drugs Exp Clin Res; 1999; 25(5):219-25. PubMed ID: 10568210.
    Abstract:
    It is generally accepted that lipid peroxides play an important role in the pathogenesis of free radical-induced cellular injury and that antioxidants such as glutathione, ascorbic acid and alpha-tocopherol are vital in cellular defense against endogenous and exogenous oxidants. The purpose of this study was to investigate the effectiveness of a natural compound, derived from lemon oil extract, in controlling free radical-induced lipid peroxidation and tissue damage in the skin. We provide evidence that a compound isolated from lemon oil, which we have called Lem1, is endowed with a strong antioxidant activity and that it is capable of inhibiting free radical-mediated reactions, evaluated by both in vitro and in vivo biochemical systems. The present study aims to give a preclinical perspective on the biochemical properties of Lem1, a natural compound, as well as to provide a better understanding of the endogenous antioxidant potential of skin and the real validity of a natural antioxidant biotechnology in the antiaging management of the skin.
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