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  • Title: Spontaneous improvement of optic pathway lesions in children with neurofibromatosis type 1.
    Author: Rossi LN, Triulzi F, Parazzini C, Maninetti MM.
    Journal: Neuropediatrics; 1999 Aug; 30(4):205-9. PubMed ID: 10569212.
    Abstract:
    Two cases of spontaneous improvement of optic pathway lesions in neurofibromatosis type 1 are reported. At time of diagnosis the children were aged 21 and 32 months respectively; they have been followed by both MRI and clinical evaluation for 5 and 4 years. MRI findings of the first 19 months of follow-up for Case 1 have been described by us before. On MRI serial evaluation, Case 1 showed an almost complete normalization of the size of lesions and a resolution of enhancement, whereas Case 2 showed a slight decrease in the size of lesions and a resolution of enhancement. From the clinical point of view Case 1 showed a normalization of his clinical signs, whereas in Case 2, a visual improvement was only slight, if at all present. In Case 1, the clinical improvement seemed to follow the spontaneous regression of the lesions detected by MRI.
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