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  • Title: Activation of channel activity of the NMDA receptor-PSD-95 complex by guanylate kinase-associated protein (GKAP).
    Author: Yamada Y, Chochi Y, Ko JA, Sobue K, Inui M.
    Journal: FEBS Lett; 1999 Sep 24; 458(3):295-8. PubMed ID: 10570927.
    Abstract:
    The channel-associated protein PSD-95 functionally modulates NMDA receptor channels, interacting with the channels via PDZ domain of PSD-95. PSD-95 also interacts with guanylate kinase-associated protein (GKAP) through the guanylate kinase-like domain of PSD-95. Here we report that GKAP markedly potentiates the channel activity of the receptor-PSD-95 complex. However, GKAP had no effect on basic properties of the channels nor on PSD-95-induced changes in channel properties. Thus, GKAP affects the channel activity of the NMDA receptor via PSD-95 quantitatively, which may make signal transmission more efficient at postsynaptic sites.
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