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  • Title: [Results of immunotherapy of acute leukemias with BCG vaccine of Polish production].
    Author: Kardaszewicz E, Japa J.
    Journal: Acta Haematol Pol; 1975; 6(2):149-55. PubMed ID: 1057344.
    Abstract:
    In 18 patients with acute leukaemia complete remission was obtained by chemotherapy and it was tried then to prolong remissions repeating at weekly intervals BCG immunization by the method of searification. In one patient no response was obtained, in 5 cases leukaemic exacerbations occurred after withdrawal of cytostatic agent. Twelve patients were maintained in complete remission during BCG vaccinations for 3.5 to 37 months. Presently only 2 patients remain in remission from 14 to 37 months with repeated BCG vaccinations only. In the remaining cases exacerbations developed after 3 to 17 months of vaccinations. The same cytostatic agents were administered to which the patients had responded previously favourably before starting vaccinations and new remissions were obtained again lasting from 3 to 24 months. Six patients died 4 to 19 months after withdrawal of BCG vaccinations. Autopsy confirmed the diagnosis of acute leukaemia.
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