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  • Title: Unsymmetrical cyclic ureas as HIV-1 protease inhibitors: novel biaryl indazoles as P2/P2' substituents.
    Author: Patel M, Rodgers JD, McHugh RJ, Johnson BL, Cordova BC, Klabe RM, Bacheler LT, Erickson-Viitanen S, Ko SS.
    Journal: Bioorg Med Chem Lett; 1999 Nov 15; 9(22):3217-20. PubMed ID: 10576691.
    Abstract:
    The preparation of unsymmetrical cyclic ureas bearing novel biaryl indazoles as P2/P2' substituents was undertaken, utilizing a Suzuki coupling reaction as the key step. Compound 6i was equipotent to the lead compound of the series SE063.
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