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  • Title: Structural study of fucoidan from Cladosiphon okamuranus TOKIDA.
    Author: Nagaoka M, Shibata H, Kimura-Takagi I, Hashimoto S, Kimura K, Makino T, Aiyama R, Ueyama S, Yokokura T.
    Journal: Glycoconj J; 1999 Jan; 16(1):19-26. PubMed ID: 10580647.
    Abstract:
    A structural study was carried out on a fucoidan isolated from the brown seaweed Cladosiphon okamuranus. The polysaccharide contained fucose, glucuronic acid and sulfate in a molar ratio of about 6.1 : 1.0 : 2.9. The results of Smith degradation showed that this polysaccharide has a linear backbone of 1-->3-linked alpha-fucopyranose with a half sulfate substitution at the 4-positions, and a portion of the fucose residues was O-acetylated. The data obtained from partial acid hydrolysis, a methylation analysis and NMR spectra indicated that the alpha-glucuronic acid residue is linked to the 2-positions of the fucose residues, which were not substituted by a sulfate group. These results indicated that the average structure of this fucoidan is as follows: -[(-->3Fuc-4(+/-OSO3-)alpha1-)5-->3[GlcA alpha1-->2]Fuc alpha1-]n-. (Half of each fucose residue was sulfated. One O-acetyl ester was present in every 6 fucose residues.)
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