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  • Title: Population choice in mapping genes for complex diseases.
    Author: Wright AF, Carothers AD, Pirastu M.
    Journal: Nat Genet; 1999 Dec; 23(4):397-404. PubMed ID: 10581024.
    Abstract:
    The difficulty of identifying susceptibility genes for common diseases has polarized geneticists' views on what disease models are appropriate and how best to proceed once high-density genome maps become available. Different disease models have different implications for using linkage or linkage-disequilibrium-based approaches for mapping complex disease genes. We argue that the choice of study population is a critical factor when designing a study, and that genetically simplified isolates are more useful than diverse continental populations under most assumptions.
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