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  • Title: [The influences of genetic and environmental factors on plasma plasminogen activator inhibitor-1 levels in patients with essential hypertension].
    Author: Song Y, Xu W, Chen Y, Che L, Wang Q, Zhou X, Wu J.
    Journal: Zhonghua Yi Xue Yi Chuan Xue Za Zhi; 1999 Dec; 16(6):374-6. PubMed ID: 10581347.
    Abstract:
    OBJECTIVE: To investigate the influence of a 4G/5G polymorphism in the PAI-1 gene promoter and environmental factors on plasma plasminogen activator inhibitor-1(PAI-1) levels in subjects with essential hypertension. METHODS: A total of 240 patients with essential hypertension(males 120, females 120, aged 33-89 years, mean 65 years) were randomly enrolled in this study. Plasma PAI-1 antigen was measured by ELISA. The 4G/5G polymorphism was analyzed by the allele specific oligonucleotide hybridization method. RESULTS: Plasma PAI-1 levels were significantly associated with 4G/5G polymorphism with the highest levels occurring in subjects with 4G/4G genotype, the intermediate levels in 4G/5G subjects and the lowest levels in 5G/5G subjects. 4G/5G polymorphism, diabetes mellitus and triglyceride(TG) were three independent predictors of plasma PAI-1 levels in a stepwise multiple regression model. Furthermore, the relationship between plasma PAI-1 levels and TG was genotype dependent. CONCLUSION: Plasma PAI-1 levels are not only under genetic control, but also influenced by several environmental factors. There is an interaction between genetic and environmental factors.
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