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  • Title: Low frequency of the TEL/AML1 fusion gene in acute lymphoblastic leukaemia in Spain.
    Author: García-Sanz R, Alaejos I, Orfão A, Rasillo A, Chillón MC, Tabernero MD, Mateos MV, López-Pérez R, González D, Balanzategui A, González M, San Miguel JF, Bortolucci A.
    Journal: Br J Haematol; 1999 Dec; 107(3):667-9. PubMed ID: 10583273.
    Abstract:
    We report on a series of Spanish patients with acute lymphoblastic leukaemia in whom the t(12;21) [TEL/AML1] translocation could not be identified with two sensitive techniques: reverse transcript-polymerase chain reaction (RT-PCR) and fluorescence in-situ hybridization (FISH). 101 cases were analysed: 38 children (29 B-cell precursor; nine T-cell precursor) and 63 adults (48 B-cell precursor; 15 T-cell precursor). Specific RT-PCR to amplify the TEL/AML1 fusion transcript was negative in all 101 cases. Moreover, all 38 paediatric samples were also negative by interphase FISH analysis for the presence of the TEL/AML1 fusion. These results suggest the existence of geographic/race variations in the genotype of acute lymphoblastic leukaemia (ALL).
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