These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Amifostine--a radioprotector in locally advanced head and neck tumors.
    Author: Schönekäs KG, Wagner W, Prott FJ.
    Journal: Strahlenther Onkol; 1999 Nov; 175 Suppl 4():27-9. PubMed ID: 10584137.
    Abstract:
    PURPOSE: There are some preliminary informations about the beneficial use of amifostine in avoiding side effects in patients with head and neck tumors who underwent radiotherapy. PATIENTS AND METHOD: Amifostine was given as daily intravenous application (500 mg) 10 to 15 minutes prior to radiotherapy in 20 patients. The results were compared with another collective of patients which was similar. RESULTS: According to the WHO score mucositis became manifest in 10 patients (Grade I) and 4 patients (Grade II) in the amifostine group vs 9 patients (Grade II), 6 patients (Grade III) and 1 patient (Grade IV) in the control group. Xerostomia has been seen in 15 patients (Grade I) and 5 patients (Grade II) after administration of amifostine. Without the drug 2 patients suffered from xerostomia (Grade I), 8 patients (Grade II) and 8 patients (Grade III), respectively. Administering amifostine had been feasible and non problematic. Only a small rate of toxic side effects like nausea (11%) or emesis (4%) was documented. CONCLUSIONS: Amifostine is an effective radioprotector decreasing acute and late side effects in patients with head and neck tumors.
    [Abstract] [Full Text] [Related] [New Search]