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  • Title: IGF-I promotes peripheral nervous system myelination.
    Author: Cheng HL, Russell JW, Feldman EL.
    Journal: Ann N Y Acad Sci; 1999 Sep 14; 883():124-30. PubMed ID: 10586238.
    Abstract:
    Insulin-like growth factor-I (IGF-I) promotes the proliferation and differentiation of Schwann cells (SC). We use SC/dorsal root ganglion neuron (DRG) cocultures to examine the effects of IGF-I on the interaction between axons and SC. As SC extend processes toward the axon in the presence of IGF-I, these processes attach to and ensheath axons. Continued IGF-I exposure leads to enhanced P0 expression and long-term myelination. No myelination occurs in the absence of IGF-I. These data imply that IGF-I is critical not only for SC attachment and ensheathment of axons but also for long-term myelination.
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