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  • Title: [Results of combined chemotherapy in treatment-resistant leukaemia of adults (author's transl)].
    Author: Bruntsch U, Osieka R, GAllmeier WM, Seeber S, Schmidt CG.
    Journal: Dtsch Med Wochenschr; 1975 Nov 28; 100(48):2478-82. PubMed ID: 1059536.
    Abstract:
    In 21 patients with acute leukaemia not or no longer responsive to conventional chemotherapy, and in four patients with chronic myeloid leukaemia in the blast phase, intensive combination treatment was started with thioguanine, daunomycine, cytarabine, methotrexate, prednisone, cyclophosphamide, and vincristine. Six patients with acute leukaemia went into complete remission, three into partial remission. The mean duration of remission was relatively short at 11 weeks. Of the four patients in the blast phase of chronic myeloid leukaemia two had objective and subjective remission. The toxicity of the combined treatment was not marked and subjective tolerance good. Such combined treatment is a realistic means of managing treatment-resistant acute leukaemia and chronic myeloid leukaemia in the blast phase.
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