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  • Title: Biopharmaceutical drug development: Filgrastim (r-metHuG-CSF) use in patients with HIV infection.
    Author: Foote M, Welch W.
    Journal: J Hematother Stem Cell Res; 1999; 8 Suppl 1():S3-8. PubMed ID: 10596029.
    Abstract:
    Hematopoietic growth factors are well known to increase neutrophil counts and support the administration of myelotoxic and myelosuppressive therapies, especially chemotherapies. Filgrastim (r-metHuG-CSF) has been used in the setting of HIV disease to treat neutropenia and HIV-associated neutrophil defects. This article reviews the biology, product characteristics, and preclinical and clinical development of Filgrastim. Emphasis is given on the use of Filgrastim in the setting of HIV infection and AIDS.
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