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  • Title: A novel depot preparation of desferrioxamine-B: development of formulation principles.
    Author: Lowther N, Sparks K, Nicklin J, Jin Y.
    Journal: Drug Dev Ind Pharm; 1999 Nov; 25(11):1157-66. PubMed ID: 10596353.
    Abstract:
    This report describes the feasibility of simple oil-based depot formulations of a novel n-decanesulfonate salt of the iron chelator desferrioxamine-B. After subcutaneous administration in rodents, desferrioxamine-B n-decanesulfonate depot induces both (a) prolonged release of drug and (b) an increase of at least threefold to fourfold in iron excretion efficiency compared with the parent compound Desferal (desferrioxamine-B mesylate). Optimization experiments probing vehicle composition, surfactant loading, drug loading, and particle size distribution of the depot preparation are described, and the physiochemical stability of an identified pilot formulation is assessed.
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