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Title: Granulocyte colony-stimulating factor: its potential role in infectious disease. Author: Hartung T. Journal: AIDS; 1999; 13 Suppl 2():S3-9. PubMed ID: 10596675. Abstract: Studies on the role of endogenous granulocyte colony-stimulating factor (G-CSF) in host defense indicate that, in addition to its anti-infectious role, this cytokine has an immunomodulatory function and also augments antibiotic efficacy. Pre-clinical and clinical trials with Filgrastim, recombinant-methionyl human G-CSF, in neutropenic and non-neutropenic infections demonstrate a reduction in morbidity and mortality. This is attributed to Filgrastim's ability to control infectious complications and permit continuation of immunosuppressive therapies.[Abstract] [Full Text] [Related] [New Search]