These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Tumor necrosis factor-alpha impairs contact hypersensitivity induction after ultraviolet B radiation via TNF-receptor 2 (p75).
    Author: Kurimoto I, Streilein JW.
    Journal: Exp Dermatol; 1999 Dec; 8(6):495-500. PubMed ID: 10597139.
    Abstract:
    Acute, low dose ultraviolet B radiation (UVR) impairs induction of contact hypersensitivity (CH) in genetically susceptible mice. Polymorphic alleles at the TNF-alpha locus dictate the susceptibility phenotype, and neutralizing anti-TNF-alpha antibodies restore CH induction in mice exposed to UVR. This circumstantial evidence strongly implicates TNF-alpha in the pathogenesis of failed CH induction after UVR. Using mice genetically deficient in TNF-receptor 1 (p55) or TNF-receptor 2 (p75), we now report that the capacity of TNF-alpha to impair CH induction after UVR required signaling via TNF-receptor 2, rather than TNF-receptor 1. Moreover, acting via the same receptor, TNF-alpha altered the density and morphology of class II MHC-bearing epidermal Langerhans cells. However, UVR retained its capacity to induce tolerance in both TNF-receptor 1 and TNF-receptor 2 deficient mice, indicating that TNF-alpha plays no role in the systemic immune deficit created by UVR.
    [Abstract] [Full Text] [Related] [New Search]