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  • Title: Brain metastasis from hepatocellular carcinoma after radical hepatectomy.
    Author: Asahara T, Yano M, Fukuda S, Fukuda T, Nakahara H, Katayama K, Itamoto T, Dohi K, Nakanishi T, Kitamoto M, Azuma K, Ito K, Moriwaki K, Yuge O, Shimamoto F.
    Journal: Hiroshima J Med Sci; 1999 Sep; 48(3):91-4. PubMed ID: 10598411.
    Abstract:
    Brain metastasis from hepatocellular carcinoma (HCC) is a rare, yet perplexing problem in patients with cancer. We report on 5 patients with metastasis of HCC to the brain after radical hepatectomy. Intrahepatic recurrence occurred in 3 patients, and distant metastasis to sites other than the brain was observed in 3 patients (lung, 2; bone, 1). The symptoms for brain metastasis included headache, hemiparesis, and vomiting. Hemorrhage was found in 4 of 5 patients. All patients had a single nodular lesion in the brain. The alpha-fetoprotein levels were more than 10,000 ng/ml in 4 patients. Two patients underwent surgical resection, 1 received cranial irradiation, and 2 were administered corticosteroids. The interval between diagnosis of the primary cancer and detection of brain metastasis ranged from 2 to 54 months. The mean survival period was only 3 months after diagnosis of brain metastasis. All 5 patients died of neurologic causes. Because no effective treatment for brain metastasis from HCC is available, further study is needed.
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