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  • Title: Parotid carcinoma as a second malignancy after treatment of childhood acute lymphoblastic leukemia.
    Author: Prasannan L, Pu A, Hoff P, Weatherly R, Castle V.
    Journal: J Pediatr Hematol Oncol; 1999; 21(6):535-8. PubMed ID: 10598668.
    Abstract:
    The occurrence of second malignant neoplasms (SMN) in children who survive their primary malignancy is a major cause for concern. Two children with diagnoses of intermediate-risk acute lymphoblastic leukemia (ALL) at 22 months and 2 years of age were treated with multiagent chemotherapy and prophylactic cranial irradiation. They experienced painless parotid swelling 6 and 7 years after successful treatment of the ALL. The patients underwent total parotidectomy, and a diagnosis of mucoepidermoid carcinoma was made. Both patients experienced transient facial nerve paresis. The incidence of SMN in children successfully treated for primary malignancies is 3% to 12%. Salivary gland tumors are being increasingly described in this setting. Long-term follow-up for survivors of childhood ALL is recommended with prompt assessment and resection of parotid swellings, particularly in children who have received cranial irradiation.
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